Endocrine Abstracts

Thyroid hormone (TH) plays an important role for brain development. As the fetal thyroid gland only starts providing hormone at the end of pregnancy, the developing brain crucially depends on maternal thyroid hormone in early developmental periods. In previous studies, we have observed that in particular the central control of cardiovascular functions critically depends on maternal thyroid hormone for proper development; however, the precise window when the hormone is benefici...

Thyroid hormones play an essential role for the embryonal development of the cardiovascular system including its central control mechanisms. Particularly the latter critically depends on maternal thyroid hormone, as the embryo doesn’t produce own thyroid hormone until late in pregnancy. However, the precise window of action has remained undetermined, and it is therefore unclear whether alterations in maternal thyroid hormone directly affect the offspring’s cardiac fu...

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

It is well established that thyroid hormones (TH) possess the ability to regulate body temperature. Thermogenesis can be induced peripherally in fat and muscle, but the active hormone T3 can also act centrally in the brain to raise the body temperature via the sympathetic nervous system. In recent studies, T3 treatment in mice has been shown to elevate the body temperature even far below thermoneutrality. This indicates that the induced hyperthyroidism causes a state of pyrexi...

Objectives: Thyroid hormones (TH) affect cardiovascular functions via direct actions on the heart and via indirect actions on central nervous system. Mutations in TH receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.Methods: The current experiments aimed at investigating the role of peripheral and central TR&...